Files and links (1)
Published (Version of record)CC BY-NC-ND V4.0, Open Access
Journal article
Wireless Optogenetic Stimulation of Oxytocin Neurons in a Semi-natural Setup Dynamically Elevates Both Pro-social and Agonistic Behaviors
Neuron, Vol.107(4), pp.644-655
19/Aug/2020
Abstract
Complex behavioral phenotyping techniques are becoming more prevalent in the field of behavioral neuroscience, and thus methods for manipulating neuronal activity must be adapted to fit into such paradigms. Here, we present a head-mounted, magnetically activated device for wireless optogenetic manipulation that is compact, simple to construct, and suitable for use in group-living mice in an enriched semi-natural arena over several days. Using this device, we demonstrate that repeated activation of oxytocin neurons in male mice can have different effects on pro-social and agonistic behaviors, depending on the social context. Our findings support the social salience hypothesis of oxytocin and emphasize the importance of the environment in the study of social neuromodulators. Our wireless optogenetic device can be easily adapted for use in a variety of behavioral paradigms, which are normally hindered by tethered light delivery or a limited environment.
Details
- Title
- Wireless Optogenetic Stimulation of Oxytocin Neurons in a Semi-natural Setup Dynamically Elevates Both Pro-social and Agonistic Behaviors
- Creators
- Sergey Anpilov (null) - The Weizmann Institute of Science, Department of NeurobiologyYair Shemesh (null) - The Weizmann Institute of Science, Department of NeurobiologyNoa Eren (null) - The Weizmann Institute of Science, Department of NeurobiologyHala Harony-Nicolas (null) - University of Haifa (Israel, Haifa)Asaf Benjamin (null) - The Weizmann Institute of Science, Department of NeurobiologyJulien Dine (null) - Max Planck Institute of Psychiatry (Germany, Munich)Vinicius E. M. Oliveira (null) - University of Regensburg (Germany, Regensburg)Oren Forkosh (null) - Max Planck Institute of Psychiatry (Germany, Munich)Stoyo Karamihalev (null) - Max Planck Institute of Psychiatry (Germany, Munich)Rosa-Eva Huttl (null) - Max Planck Institute of Psychiatry (Germany, Munich)Noa Feldman (null) - The Weizmann Institute of Science, Department of NeurobiologyRyan Berger (null) - Weizmann Institute of Science (Israel, Rehovot)Avi Dagan (null) - Weizmann Institute of Science (Israel, Rehovot)Gal Chen (null) - Weizmann Institute of Science (Israel, Rehovot)Inga D. Neumann (null) - University of Regensburg (Germany, Regensburg)Shlomo Wagner (null) - University of Haifa (Israel, Haifa)Ofer Yizhar (null) - The Weizmann Institute of Science, Department of NeurobiologyAlon Chen (Corresponding Author) - The Weizmann Institute of Science, Department of Neurobiology
- Resource Type
- Journal article
- Publication Details
- Neuron, Vol.107(4), pp.644-655; 19/Aug/2020
- Number of pages
- 12
- Language
- English
- DOI
- https://doi.org/10.1016/j.neuron.2020.05.028
- Grant note
- The authors wish to thank Franck Touboul for assistance with DeepLabCut tracking, Dr. Jessica Keverne for writing and editing support and advice, and Dr. Ron Rotkopf for assistance with statistical analyses. A.C. is the incumbent of the Vera and John Schwartz Family Professorial Chair in Neurobiology at the Weizmann Institute and the head of the Max Planck Society–Weizmann Institute of Science Laboratory for Experimental Neuropsychiatry and Behavioral Neurogenetics gratefully funded by the Max Planck Foundation. This work is supported by an FP7 Grant from the European Research Council (260463, A.C.); a research grant from the Israel Science Foundation (1565/15, A.C.); and the ERANET Program, supported by the Chief Scientist Office of the Israeli Ministry of Health (3-11389, A.C.); the project was funded by the Federal Ministry of Education and Research under the funding code 01KU1501A (A.C.); I-CORE Program of the Planning and Budgeting Committee and The Israel Science Foundation (grant no. 1916/12 to A.C.); Ruhman Family Laboratory for Research in the Neurobiology of Stress (A.C.); research support from Bruno and Simone Licht; the Perlman Family Foundation, founded by Louis L. and Anita M. Perlman (A.C.); the Adelis Foundation (A.C.); and Sonia T. Marschak (A.C.). Author Contributions Conceptualization, S.A., Y.S., and A.C.; Methodology, S.A., Y.S., O.F., H.H.-N., and A.D.; Software, A.B. and O.F.; Investigation, S.A., Y.S., N.E., JD, R.-E.H., V.E.M.O., and G.C.; Validation, S.A., Y.S., N.E., and H.H.-N.; Formal Analysis, S.A., Y.S., N.E., A.B., and J.D., V.E.M.O., S.K., N.F., and R.B.; Writing, N.E., S.A., and Y.S.; Visualization, S.A.; Funding Acquisition, A.C.; Resources, O.Y. and S.W.; Supervision: A.C., O.Y., S.W., and I.D.N.
- Record Identifier
- 993267636003596
Metrics
6 Record Views