Journal article
Time for Food: The Intimate Interplay between Nutrition, Metabolism, and the Circadian Clock
Cell, Vol.161(1), pp.84-92
26/Mar/2015
Abstract
The circadian clock, a highly specialized, hierarchical network of biological pacemakers, directs and maintains proper rhythms in endocrine and metabolic pathways required for organism homeostasis. The clock adapts to environmental changes, specifically daily light-dark cycles, as well as rhythmic food intake. Nutritional challenges reprogram the clock, while time-specific food intake has been shown to have profound consequences on physiology. Importantly, a critical role in the clock-nutrition interplay appears to be played by the microbiota. The circadian clock appears to operate as a critical interface between nutrition and homeostasis, calling for more attention on the beneficial effects of chrono-nutrition.
Details
- Title
- Time for Food; The Intimate Interplay between Nutrition, Metabolism, and the Circadian Clock
- Creators
- Gad Asher (Corresponding Author) - 972WIS_INST___112Paolo Sassone-Corsi (Corresponding Author) - University of California, Irvine
- Resource Type
- Journal article; Review
- Publication Details
- Cell, Vol.161(1), pp.84-92; 26/Mar/2015
- Number of pages
- 9
- Language
- English
- DOI
- https://doi.org/10.1016/j.cell.2015.03.015
- Grant note
- Due to space limitations, we were, unfortunately, unable to comment on all of the relevant studies and thus apologize for not citing all pertinent references. Work in the laboratory of G.A. was supported by the Israel Science Foundation (ISF 138/12), the Abish-Frenkel Foundation, the HFSP Career Development Award (HFSP CDA00014/2012), and the European Research Council (ERC-2011 METACYCLES 310320). Work in the laboratory of P.S.-C. is supported by the NIH, ABOCA SpA (Italy), Institut National de la Sante et Recherche Medicale (INSERM, France), and a Novo Nordisk Foundation Challenge Grant.
- Record Identifier
- 993262116803596
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