Journal article
The metabolism and function of sphingolipids and glycosphingolipids
Cellular and Molecular Life Sciences, Vol.64(17), pp.2270-2284
Sep/2007
Abstract
Sphingolipids and glycosphingolipids are emerging as major players in many facets of cell physiology and pathophysiology. We now present an overview of sphingolipid biochemistry and physiology, followed by a brief presentation of recent advances in translational research related to sphingolipids. In discussing sphingolipid biochemistry, we focus on the structure of sphingolipids, and their biosynthetic pathways - the recent identification of most of the enzymes in this pathway has led to significant advances and better characterization of a number of the biosynthetic steps, and the relationship between them. We then discuss some roles of sphingolipids in cell physiology, particularly those of ceramide and sphingosine-1-phosphate, and mention current views about how these lipids act in signal transduction pathways. We end with a discussion of sphingolipids and glycosphingolipids in the etiology and pathology of a number of diseases, such as cancer, immunity, cystic fibrosis, emphysema, diabetes, and sepsis, areas in which sphingolipids are beginning to take a central position, even though many of the details remain to be elucidated.
Details
- Title
- The metabolism and function of sphingolipids and glycosphingolipids
- Creators
- S. Lahiri (null)Anthony H. Futerman (null) - 972WIS_INST___112
- Resource Type
- Journal article; Review
- Publication Details
- Cellular and Molecular Life Sciences, Vol.64(17), pp.2270-2284; Sep/2007
- Number of pages
- 15
- Language
- English
- DOI
- https://doi.org/10.1007/s00018-007-7076-0
- Record Identifier
- 993262861303596
Metrics
7 Record Views