Journal article
Synthesis of Peptides and Pyrazines from β‐Amino Alcohols through Extrusion of H2 Catalyzed by Ruthenium Pincer Complexes: Ligand-Controlled Selectivity
Angewandte Chemie - International Edition, Vol.50(51), pp.12240-12244
16/Dec/2011
Abstract
Your choice: The choice of the Ru‐pincer‐complex catalyst determines if peptides or pyrazines are formed from β‐amino alcohols. Use of PNN complex 1 leads to linear poly(alanine) or to cyclic dipeptides, depending on the R group (see scheme). With the PNP complex 2, pyrazines are formed. These reactions are homogeneously catalyzed under neutral conditions and are environmentally benign.
Details
- Title
- Synthesis of Peptides and Pyrazines from β‐Amino Alcohols through Extrusion of H2 Catalyzed by Ruthenium Pincer Complexes; Ligand-Controlled Selectivity
- Creators
- Boopathy Gnanaprakasam (null)Ekambaram Balaraman (null) - The Weizmann Institute of ScienceYehoshoa Ben-David (null) - The Weizmann Institute of ScienceDavid Milstein (null) - The Weizmann Institute of Science
- Resource Type
- Journal article
- Publication Details
- Angewandte Chemie - International Edition, Vol.50(51), pp.12240-12244; 16/Dec/2011
- Number of pages
- 5
- Language
- English
- DOI
- https://doi.org/10.1002/anie.201105876
- Grant note
- This research was supported by the European Research Council under the FP7 framework, (ERC No 246837), by the Israel Science Foundation, and by the MINERVA Foundation. D. M. is the holder of the Israel Matz Professorial Chair of Organic Chemistry._ALMAME_DELIMITER_
- Record Identifier
- 993267885503596
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