Spatially encoded pulse sequences for the acquisition of high resolution NMR spectra in inhomogeneous fields

Boaz Shapira; Lucio Frydman

doi:10.1016/j.jmr.2006.04.012

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Spatially encoded pulse sequences for the acquisition of high resolution NMR spectra in inhomogeneous fields

Journal article

Peer reviewed

Spatially encoded pulse sequences for the acquisition of high resolution NMR spectra in inhomogeneous fields

Boaz Shapira and Lucio Frydman

Journal of Magnetic Resonance, Vol.182(1), pp.12-21

Sep/2006

DOI: https://doi.org/10.1016/j.jmr.2006.04.012

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Abstract

We have recently proposed a protocol for retrieving nuclear magnetic resonance (NMR) spectra based on a spatially-dependent encoding of the MR interactions. It has also been shown that the spatial selectivity with which spins are manipulated during such encoding opens up new avenues towards the removal of magnetic field inhomogeneities; not by demanding extreme B-o field uniformities, but rather by compensating for the dephasing effects introduced by the field distribution at a radiofrequency excitation and/or refocusing level. The present study discusses in further detail a number of strategies deriving from this principle, geared at acquiring both uni- as well as multi-dimensional spectroscopic data at high resolution conditions. Different variants are presented, tailored according to the relative sensitivity and chemical nature of the spin system being explored. In particular a simple multi-scan experiment is discussed capable of affording substantial improvements in the spectral resolution, at nearly no sensitivity or scaling penalties. This new compensation scheme is therefore well-suited for the collection of high-resolution data in low-field systems possessing limited signal-to-noise ratios, where magnetic field heterogeneities might present a serious obstacle. Potential areas of applications of these techniques include high-field in vivo NMR studies in regions near tissue/air interfaces, clinical low field MR spectroscopy on relatively large off-center volumes difficult to shim, and ex situ NMR. The principles of the different compensation methods are reviewed and experimentally demonstrated for one-dimensional inhomogeneities; further improvements and extensions are briefly discussed. (c) 2006 Elsevier Inc. All rights reserved.

Details

Title: Spatially encoded pulse sequences for the acquisition of high resolution NMR spectra in inhomogeneous fields
Creators: Boaz Shapira (null)
Lucio Frydman (null) - 972WIS_INST___136
Resource Type: Journal article
Publication Details: Journal of Magnetic Resonance, Vol.182(1), pp.12-21; Sep/2006
Number of pages: 10
Language: English
DOI: https://doi.org/10.1016/j.jmr.2006.04.012
Record Identifier: 993267641803596

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