Journal article
Single-cell sequencing-based technologies will revolutionize whole-organism science
Nature Reviews Genetics, Vol.14(9), pp.618-630
30/Jul/2013
Abstract
The unabated progress in next-generation sequencing technologies is fostering a wave of new genomics, epigenomics, transcriptomics and proteomics technologies. These sequencing-based technologies are increasingly being targeted to individual cells, which will allow many new and longstanding questions to be addressed. For example, single-cell genomics will help to uncover cell lineage relationships; single-cell transcriptomics will supplant the coarse notion of marker-based cell types; and single-cell epigenomics and proteomics will allow the functional states of individual cells to be analysed. These technologies will become integrated within a decade or so, enabling high-throughput, multi-dimensional analyses of individual cells that will produce detailed knowledge of the cell lineage trees of higher organisms, including humans. Such studies will have important implications for both basic biological research and medicine.
Details
- Title
- Single-cell sequencing-based technologies will revolutionize whole-organism science
- Creators
- Ehud Shapiro (null) - 972WIS_INST___83Tamir Biezuner (null) - The Weizmann Institute of ScienceSten Linnarsson (null) - Karolinska Institutet
- Resource Type
- Journal article; Review
- Publication Details
- Nature Reviews Genetics, Vol.14(9), pp.618-630; 30/Jul/2013
- Number of pages
- 13
- Language
- English
- DOI
- https://doi.org/10.1038/nrg3542
- Grant note
- European Research Council [261063]; Swedish Research Council STARGET consortium; European Union FP7-ERC-AdG grant; Kenneth and Sally Leafman Appelbaum Discovery Fund. The work of S.L. was supported by grant 261063 from the European Research Council and by the Swedish Research Council STARGET consortium. The work of E.S. and T.B. was supported by The European Union FP7-ERC-AdG grant and by a grant from the Kenneth and Sally Leafman Appelbaum Discovery Fund. E.S. is the Incumbent of The Harry Weinrebe Professorial Chair of Computer Science and Biology. The contribution of E.S. to this Review was inspired by a research proposal prepared by E.S. in collaboration with I. Amit, A. Tanay and M. Schwarz._ALMAME_DELIMITER_
- Record Identifier
- 993265427303596
Metrics
8 Record Views