Journal article
Simple and Efficient Catalytic Reaction for the Selective Deuteration of Alcohols
ACS Catalysis, Vol.3(3), pp.448-452
Mar/2013
Abstract
A highly efficient system for the catalytic deuteration of alpha and beta CH bonds of primary and secondary alcohols has been developed. The deuterium source is D2O. Together with the low catalyst loadings and the simple experimental setup, the reaction has direct application to the synthesis of bioactive isotopologues and the direct synthesis of fully deuterated substrates, such as ethanol-d(6). The current system represents a significant advance in practicality for homogeneous metal catalyzed systems that carry out H/D exchange in organic substrates with water.
Details
- Title
- Simple and Efficient Catalytic Reaction for the Selective Deuteration of Alcohols
- Creators
- Eugene Khaskin (null) - The Weizmann Institute of ScienceDavid Milstein (null) - The Weizmann Institute of Science
- Resource Type
- Journal article
- Publication Details
- ACS Catalysis, Vol.3(3), pp.448-452; Mar/2013
- Number of pages
- 5
- Language
- English
- DOI
- https://doi.org/10.1021/cs400092p
- Grant note
- European Research Council (ERC) [246837]; Kimmel Center for Molecular Design; Bernice and Peter Cohn Catalysis Research FundThis research was supported by the European Research Council under the FP7 framework (ERC No 246837), by the Kimmel Center for Molecular Design, and by the Bernice and Peter Cohn Catalysis Research Fund. D.M. is the Israel Matz Professorial Chair of Organic Chemistry._ALMAME_DELIMITER_
- Record Identifier
- 993264307903596
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