Journal article
Rapid quantum image scanning microscopy by joint sparse reconstruction
Optica, Vol.6(10), pp.1290-1296
20/Oct/2019
Abstract
<p>The evolution of experimental superresolution microscopy has been accompanied by the development of advanced computational imaging capabilities. Recently introduced, quantum image scanning microscopy (Q-ISM) has successfully harnessed quantum correlations of light to establish an improved viable imaging modality that builds upon the preceding image scanning microscopy (ISM) superresolution method. While offering improved resolution, at present the inherently weak signal demands exhaustively long acquisition periods. Here we exploit the fact that the correlation measurement in Q-ISM is complementary to the standard ISM data, acquired simultaneously, and demonstrate joint sparse recovery from Q-ISM and ISM images. Reconstructions from images of fluorescent quantum dots are validated through correlative electron microscope measurements, and exhibit superior resolution enhancement as compared to Q-ISM images. In addition, the algorithmic fusion facilitates a drastic reduction in the requisite measurement duration, since low signal-to-noise-ratio Q-ISM measurements suffice for augmenting ISM images. Finally, we obtain enhanced superresolved reconstructions from short scans of a biological sample labeled with quantum dots, demonstrating the potential of our method for quantum imaging in life science microscopy.<br/></p>
Details
- Title
- Rapid quantum image scanning microscopy by joint sparse reconstruction
- Creators
- Uri Rossman (null) - 972WIS_INST___89Ron Tenne (null) - 972WIS_INST___89Oren Solomon (null) - Technion – Israel Institute of TechnologyIfat Kaplan-Ashiri (null) - 972WIS_INST___100Tali Dadosh (null) - 972WIS_INST___100Yonina C. Eldar (null) - 972WIS_INST___83Dan Oron (Corresponding Author) - 972WIS_INST___89
- Resource Type
- Journal article
- Publication Details
- Optica, Vol.6(10), pp.1290-1296; 20/Oct/2019
- Number of pages
- 7
- Language
- English
- DOI
- https://doi.org/10.1364/OPTICA.6.001290
- Grant note
- Funding: European Research Council (POC project SFICAM); Israel Science Foundation (ICore program); Crown Photonics Center Acknowledgment: The authors would like to thank Prof. Yuval Ebenstein for the preparation of the biological sample. The SEM imaging was done at the Moskowitz Center for Nano and Nano-Bio Imaging, Weizmann Institute of Science. D. O. is the incumbent of the Harry Weinrebe Professorial Chair of Laser Physics. Disclosure: A provisional patent on the reported methodhas been submitted.
- Record Identifier
- 993266654603596
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