Journal article
Personalized Nutrition by Prediction of Glycemic Responses.
Cell, Vol.163(5), pp.1079-94
Nov/2015
Abstract
Elevated postprandial blood glucose levels constitute a global epidemic and a major risk factor for prediabetes and type II diabetes, but existing dietary methods for controlling them have limited efficacy. Here, we continuously monitored week-long glucose levels in an 800-person cohort, measured responses to 46,898 meals, and found high variability in the response to identical meals, suggesting that universal dietary recommendations may have limited utility.We devised a machine-learning algorithm that integrates blood parameters, dietary habits, anthropometrics, physical activity, and gut microbiota measured in this cohort and showed that it accurately predicts personalized postprandial glycemic response to real-life meals. We validated these predictions in an independent 100-person cohort. Finally, a blinded randomized controlled dietary intervention based on this algorithm resulted in significantly lower postprandial responses and consistent alterations to gut microbiota configuration. Together, our results suggest that personalized diets may successfully modify elevated postprandial blood glucose and its metabolic consequences. VIDEO ABSTRACT.
Details
- Title
- Personalized Nutrition by Prediction of Glycemic Responses.
- Creators
- David Zeevi (null) - 972WIS_INST___83Tal Korem (null) - 972WIS_INST___83Niv Zmora (null) - 972WIS_INST___120David Israeli (null)Daphna Rothschild (null)Adina Weinberger (null) - 972WIS_INST___83Orly Ben-Yacov (null)Dar Lador (null) - The Weizmann Institute of ScienceSagi, Tali Avnit Sagi (null) - The Weizmann Institute of ScienceMaya Lotan-Pompan (null) - The Weizmann Institute of ScienceJotham Suez (null) - 972WIS_INST___120Jemal Ali Mahdi (null)Elad Matot (null) - The Weizmann Institute of ScienceGal Malka (null) - The Weizmann Institute of ScienceNoa Kosower (null) - The Weizmann Institute of ScienceMichal Rein (null) - The Weizmann Institute of ScienceGili Zilberman-Schapira (null)Lenka Dohnalova (null)Meirav Pevsner-Fischer (null) - 972WIS_INST___120Rony Bikovsky (null) - The Weizmann Institute of ScienceZamir Halpern (null)Eran Elinav (null) - 972WIS_INST___120Eran Segal (null) - 972WIS_INST___83
- Resource Type
- Journal article
- Publication Details
- Cell, Vol.163(5), pp.1079-94; Nov/2015
- Language
- English
- DOI
- https://doi.org/10.1016/j.cell.2015.11.001
- Record Identifier
- 993264341803596
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