Journal article
PEPTIDE THERAPY FOR DIABETES IN NOD MICE
Lancet, Vol.343(8899), pp.704-706
Mar/1994
Abstract
NOD mice spontaneously develop autoimmune diabetes that mimics insulin-dependent diabetes mellitus (IDDM) in man. A peptide of the 60 kDa heat shock protein (hsp60), designated p277, can serve as a target for diabetogenic T-cell clones, and diabetes was prevented by using the p277 peptide to turn off anti-p277 immunity early in life. We report that the p277 peptide, administered once, can arrest the autoimmune process even after it is far advanced. Successful therapy was associated with down-regulation of the autoimmune process and regression of islet inflammation. Thus the immune system is responsive to manipulation by a specific signal even in the face of a virulent, full-blown autoimmune process.
Details
- Title
- PEPTIDE THERAPY FOR DIABETES IN NOD MICE
- Creators
- D ELIAS (null)Irun R. Cohen (null) - The Weizmann Institute of Science
- Resource Type
- Journal article
- Publication Details
- Lancet, Vol.343(8899), pp.704-706; Mar/1994
- Number of pages
- 3
- Language
- English
- DOI
- https://doi.org/10.1016/S0140-6736(94)91582-2
- Scientific Unit
- The Weizmann Institute of Science
- Record Identifier
- 993266920803596
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