Journal article
Normalisation of brain connectivity through compensatory behaviour, despite congenital hand absence
eLife, Vol.4
Jan/2015
Abstract
Previously we showed, using task-evoked fMRI, that compensatory intact hand usage after amputation facilitates remapping of limb representations in the cortical territory of the missing hand (Makin et al., 2013a). Here we show that compensatory arm usage in individuals born without a hand (one-handers) reflects functional connectivity of spontaneous brain activity in the cortical hand region. Compared with two-handed controls, one-handers showed reduced symmetry of hand region inter-hemispheric resting-state functional connectivity and corticospinal white matter microstructure. Nevertheless, those one-handers who more frequently use their residual (handless) arm for typically bimanual daily tasks also showed more symmetrical functional connectivity of the hand region, demonstrating that adaptive behaviour drives long-range brain organisation. We therefore suggest that compensatory arm usage maintains symmetrical sensorimotor functional connectivity in one-handers. Since variability in spontaneous functional connectivity in our study reflects ecological behaviour, we propose that inter-hemispheric symmetry, typically observed in resting sensorimotor networks, depends on coordinated motor behaviour in daily life.
Details
- Title
- Normalisation of brain connectivity through compensatory behaviour, despite congenital hand absence
- Creators
- Avital Hahamy (null) - 972WIS_INST___123Stamatios N. Sotiropoulos (null)David Henderson Slater (null)Rafael Malach (null)Heidi Johansen-Berg (null)Tamar R. Makin (null)
- Resource Type
- Journal article
- Publication Details
- eLife, Vol.4; Jan/2015
- Number of pages
- 12
- Language
- English
- DOI
- https://doi.org/10.7554/eLife.04605
- Grant note
- European Commission EU FP7 VERE; European Commission Flagship HBP; Israel Science Foundation ICORE; Wellcome Trust; National Institute for Health Research Oxford Biomedical Research Centre; European Commission EU FP7 ABC grant [PITN-GA-2008-290011]; Royal Society Newton International Fellowship; European Commission (Marie Curie Intra- European Fellowship; Wellcome Trust Sir Henry Dale Fellowship; Royal Society Sir Henry Dale Fellowship; Israeli Presidential Bursary; Boehringer IngelheimIsraeli Presidential Bursary Avital HahamyBoehringer Ingelheim Avital HahamyEuropean Commission EU FP7 VERE Rafael MalachEuropean Commission Flagship HBP Rafael MalachIsrael Science Foundation ICORE Rafael MalachWellcome Trust Heidi Johansen-BergNational Institute for Health Research Oxford Biomedical Research Centre Heidi Johansen-BergEuropean Commission EU FP7 ABC grant (PITN-GA-2008-290011) Heidi Johansen-BergRoyal Society Newton International Fellowship Tamar R MakinEuropean Commission (Marie Curie Intra- European Fellowship Tamar R MakinWellcome Trust Sir Henry Dale Fellowship Tamar R MakinRoyal Society Sir Henry Dale Fellowship Tamar R Makin_ALMAME_DELIMITER_
- Record Identifier
- 993265298103596
Metrics
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