Journal article
Neurological Disease as a Failure of Brain-Immune Crosstalk: The Multiple Faces of Neuroinflammation
Trends in Immunology, Vol.37(10), pp.668-679
Oct/2016
Abstract
Neuroinflammation is common to various diseases of the central nervous system (CNS), but its imprecise definition has led to many misconceptions in research and clinical approaches. It is now recognized that neuroinflammation in chronic neurodegenerative conditions, including Alzheimer's disease (AD) and age-related dementia, is distinct from the inflammation that accompanies relapsing-remitting multiple sclerosis (RRMS), and its experimental animal model, experimental autoimmune encephalomyelitis (EAE). Here, we discuss the discrete features of inflammation in different CNS pathologies, given the current understanding of the CNS-immune crosstalk; the roles of the immune cells that are involved, their phenotypes, and their location and route of entry to the CNS. Understanding the term neuroinflammation to encompass a broad range of disease-specific conditions is essential for finding effective therapeutic approaches for these pathologies.
Details
- Title
- Neurological Disease as a Failure of Brain-Immune Crosstalk; The Multiple Faces of Neuroinflammation
- Creators
- Michal Schwartz (null) - 972WIS_INST___123Aleksandra Deczkowska (null) - 972WIS_INST___123
- Resource Type
- Journal article; Review
- Publication Details
- Trends in Immunology, Vol.37(10), pp.668-679; Oct/2016
- Number of pages
- 12
- Language
- English
- DOI
- https://doi.org/10.1016/j.it.2016.08.001
- Grant note
- European Commission 7th Framework Program HEALTH [279017]; ISF-Legacy Heritage Biomedical Science Partnership-research [1354/15]; Weizmann-Tanz collaboration; Maurice and Ilse Katz Professorial Chair in Neuroimmunology_ALMAME_DELIMITER_
- Record Identifier
- 993264603703596
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