Journal article
Neuritin: A gene induced by neural activity and neurotrophins that promotes neuritogenesis
Proceedings of the National Academy of Sciences of the United States of America, Vol.94(6), pp.2648-2653
Mar/1997
Abstract
Neural activity and neurotrophins induce synaptic remodeling in part by altering gene expression, A cDNA encoding a glycosylphoshatidylinositol-anchored protein was identified by screening for hippocampal genes that are induced by neural activity, This molecule, named neuritin, is expressed in postmitotic-differentiating neurons of the developing nervous system and neuronal structures associated with plasticity in the adult, Neuritin message is induced by neuronal activity and by the activity-regulated neurotrophins BDNF and NT-3. Purified recombinant neuritin promotes neurite outgrowth and arborization in primary embryonic hippocampal and cortical cultures, These data implicate neuritin as a downstream effector of activity-induced neurite outgrowth.
Details
- Title
- Neuritin; A gene induced by neural activity and neurotrophins that promotes neuritogenesis
- Creators
- GS Naeve (null)M Ramakrishnan (null)Riri Kramer (null) - The Weizmann Institute of ScienceD Hevroni (null)Y Citri (null)LE Theill (null)
- Resource Type
- Journal article
- Publication Details
- Proceedings of the National Academy of Sciences of the United States of America, Vol.94(6), pp.2648-2653; Mar/1997
- Number of pages
- 6
- Language
- English
- DOI
- https://doi.org/10.1073/pnas.94.6.2648
- Scientific Unit
- The Weizmann Institute of Science
- Record Identifier
- 993265121503596
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