An unprecedented one-step synthesis of N-substituted hydrazones by coupling of alcohols with hydrazine is reported. This partial hydrogen-borrowing reaction is catalyzed by a new manganese pincer complex under mild reaction conditions, thus liberating water and dihydrogen as the only byproducts. Mechanistic insight, based on the observation of intermediates, is provided.
Journal article
N-Substituted Hydrazones by Manganese Catalyzed Coupling of Alcohols with Hydrazine: Borrowing Hydrogen and Acceptorless Dehydrogenation in One System
Angewandte Chemie - International Edition, Vol.57(8), pp.2179-2182
19/Feb/2018
PMID: 29316100
Abstract
Details
- Title
- N-Substituted Hydrazones by Manganese Catalyzed Coupling of Alcohols with Hydrazine; Borrowing Hydrogen and Acceptorless Dehydrogenation in One System
- Creators
- David Milstein (null) - The Weizmann Institute of Science, Department of Organic ChemistryUttam Kumar Das (null) - The Weizmann Institute of Science, Department of Organic ChemistryYehoshoa Ben-David (null) - Weizmann Institute of Science (Israel, Rehovot)Yael Diskin-Posner (null) - The Weizmann Institute of Science, Department of Chemical Research Support
- Resource Type
- Journal article
- Publication Details
- Angewandte Chemie - International Edition, Vol.57(8), pp.2179-2182; 19/Feb/2018
- Number of pages
- 4
- Language
- English
- DOI
- https://doi.org/10.1002/anie.201712593
- PMID
- 29316100
- Grant note
- This research was supported by the European Research Council (ERC AdG 692775). D.M. holds the Israel Matz Professorial Chair of Organic Chemistry. U.K.D. is thankful to The Science & Engineering Research Board (SERB), DST, and Govt. of India for the SERB Overseas Postdoctoral Fellowship.
- Record Identifier
- 993265994603596
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