Journal article
Molecular Architecture and Function of Matrix Adhesions
Cold Spring Harbor perspectives in biology, Vol.3(5)
May/2011
Abstract
Cell adhesions mediate important bidirectional interactions between cells and the extracellular matrix. They provide an interactive interface between the extracellular chemical and physical environment and the cellular scaffolding and signaling machinery. This dynamic, reciprocal regulation of intracellular processes and the matrix is mediated by membrane receptors such as the integrins, as well as many other components that comprise the adhesome. Adhesome constituents assemble themselves into different types of cell adhesion structures that vary in molecular complexity and change over time. These cell adhesions play crucial roles in cell migration, proliferation, and determination of cell fate.
Details
- Title
- Molecular Architecture and Function of Matrix Adhesions
- Creators
- Benjamin Geiger (null) - 972WIS_INST___122Kenneth M. Yamada (null)
- Resource Type
- Journal article
- Publication Details
- Cold Spring Harbor perspectives in biology, Vol.3(5); May/2011
- Number of pages
- 21
- Language
- English
- DOI
- https://doi.org/10.1101/cshperspect.a005033
- Grant note
- National Institute of General Medical Sciences (NIH) [U54GM64346]; Nanotechnology Center for Mechanics in Regenerative Medicine [PN2 EY016586]; Mario Negri Institute for Pharmacological Research - Weizmann Institute of Science; Israel Science Foundation; National Institute of Dental and Craniofacial Research; National Institutes of HealthBG is the incumbent of the Erwin Neter Professorial Chair in Cell and Tumor Biology. Studies addressing the adhesome network and mechanosensitivity were supported by the National Institute of General Medical Sciences grant for the Cell Migration Consortium (NIH grant no. U54GM64346); the Nanotechnology Center for Mechanics in Regenerative Medicine (part of the NIH Nanomedicine Development Center Network; NIH grant no. PN2 EY016586), the Mario Negri Institute for Pharmacological Research - Weizmann Institute of Science Exchange Program, and the Israel Science Foundation. KMY is supported by the Intramural Research Program of the National Institute of Dental and Craniofacial Research, National Institutes of Health. The authors would like to express their gratitude to Chen Luxenburg, Tova Volberg, Ronen Zaidel-Bar, and Baruch Zimerman for providing data presented in this article. The authors also wish to thank Barbara Morgenstern for excellent editorial assistance._ALMAME_DELIMITER_
- Record Identifier
- 993264932003596
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