Journal article
Making Sense of the Yeast Sphingolipid Pathway
Journal of Molecular Biology, Vol.428(24), pp.4765-4775
04/Dec/2016
Abstract
Sphingolipids (SL) and their metabolites play key roles both as structural components of membranes and as signaling molecules. Many of the key enzymes and regulators of SL, metabolism were discovered using the yeast Saccharomyces cerevisiae, and based on the high degree of conservation, a number of mammalian homologs were identified. Although yeast continues to be an important tool for SL research, the complexity of SL structure and nomenclature often hampers the ability of new researchers to grasp the subtleties of yeast SL biology and discover new modulators of this intricate pathway. Moreover, the emergence of lipidomics by mass spectrometry has enabled the rapid identification of SL species in yeast and rendered the analysis of SL composition under various physiological and pathophysiolbgical conditions readily amenable. However, the complex nomenclature of the identified species renders much of the data inaccessible to non-specialists. In this review, we focus on parsing both the classical SL nomenclature and the nomenclature normally used during mass spectrometry analysis, which should facilitate the understanding of yeast SL data and might shed light on biological processes in which SLs are involved. Finally, we discuss a number of putative roles of various yeast SL species.
Details
- Title
- Making Sense of the Yeast Sphingolipid Pathway
- Creators
- Marton Megyeri (null) - The Weizmann Institute of ScienceH Riezman (null) - University of GenevaMaya Schuldiner (Corresponding Author) - 972WIS_INST___111Anthony H. Futerman (null) - 972WIS_INST___112
- Resource Type
- Journal article; Review
- Publication Details
- Journal of Molecular Biology, Vol.428(24), pp.4765-4775; 04/Dec/2016
- Number of pages
- 11
- Language
- English
- DOI
- https://doi.org/10.1016/j.jmb.2016.09.010
- Grant note
- Marie Curie ITN Sphingonet [289278]; SystemsX.ch; NCCR Chemical Biology; Swiss National Science Foundation Financial support from the Marie Curie ITN Sphingonet (project 289278) to M. Megyeri is gratefully acknowledged. A.H. Futerman is the Joseph Meyerhoff Professor of Biochemistry at the Weizmann Institute of Science. M. Schuldiner is an incumbent of the Dr. Gilbert Omenn and Martha Darling Professorial Chair in Molecular Genetics. H. Riezman is funded by SystemsX.ch, the NCCR Chemical Biology, and the Swiss National Science Foundation._ALMAME_DELIMITER_
- Record Identifier
- 993264401003596
Metrics
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