Journal article
Leukocyte Migration into Inflamed Tissues
Immunity, Vol.41(5), pp.694-707
Nov/2014
Abstract
Leukocyte migration through activated venular walls is a fundamental immune response that is prerequisite to the entry of effector cells such as neutrophils, monocytes, and effector T cells to sites of infection, injury, and stress within the interstitium. Stimulation of leukocytes is instrumental in this process with enhanced temporally controlled leukocyte adhesiveness and shape-changes promoting leukocyte attachment to the inner wall of blood vessels under hydrodynamic forces. This initiates polarized motility of leukocytes within and through venular walls and transient barrier disruption facilitated sequentially by stimulated vascular cells, i.e., endothelial cells and their associated pericytes. Perivascular cells such as macrophages and mast cells that act as tissue inflammatory sentinels can also directly and indirectly regulate the exit of leukocytes from the vascular lumen. In this review, we discuss current knowledge and open questions regarding the mechanisms involved in the interactions of different effector leukocytes with peripheral vessels in extralymphoid organs.
Details
- Title
- Leukocyte Migration into Inflamed Tissues
- Creators
- Sussan Nourshargh (null)Ronen Alon (null) - 972WIS_INST___120
- Resource Type
- Journal article; Review
- Publication Details
- Immunity, Vol.41(5), pp.694-707; Nov/2014
- Number of pages
- 14
- Language
- English
- DOI
- https://doi.org/10.1016/j.immuni.2014.10.008
- Grant note
- Wellcome Trust [098291/Z/12/Z]; Israel Science Foundation; US Israel Binational Science Foundation; Flight Attendant Medical Research Institute FoundationWe wish to thank H. Vega for help with figures, S. Feigelson for helpful suggestions, and A. Woodfin and M.-B. Voisin for providing the confocal images. S.N.'s research is generously funded by a Wellcome Trust Senior Investigator Award (Ref. 098291/Z/12/Z). R.A. is an incumbent of the Linda Jacobs Chair in Immune and Stem Cell Research, and his research is supported by the Israel Science Foundation, the US Israel Binational Science Foundation, and the Flight Attendant Medical Research Institute Foundation._ALMAME_DELIMITER_
- Record Identifier
- 993264444003596
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