Journal article
Layer-specific touch-dependent facilitation and depression in the somatosensory cortex during active whisking
Journal of Neuroscience, Vol.26(37), pp.9538-9547
Sep/2006
Abstract
Brains adapt to new situations by retuning their neurons. The most common form of neuronal adaptation, typically observed with repetitive stimulations of passive sensory organs, is depression (responses gradually decrease until stabilized). We studied cortical adaptation when stimuli are acquired by active movements of the sensory organ. In anesthetized rats, artificial whisking was induced at 5 Hz, and activity of individual neurons in layers 2-5 was recorded during whisking in air (Whisking condition) and whisking against an object (Touch condition). Response strengths were assessed by spike counts. Input-layer responses (Layers 4 and 5a) usually facilitated during the whisking train, whereas superficial responses (layer 2/3) usually depressed. In layers 2/3 and 4, but not 5a, responses were usually stronger during touch trials than during whisking in air. Facilitations were specific to the protraction phase; during retraction, responses depressed in all layers and conditions. These dynamic processes were accompanied by a slow positive wave of activity progressing from superficial to deeper layers and lasting for similar to 1 s, during the transient phase of response. Our results indicate that, in the cortex, adaptation does not depend only on the level of activity or the frequency of its repetition but rather on the nature of the sensory information that is conveyed by that activity and on the processing layer. The input and laminar specificities observed here are consistent with the hypothesis that the paralemniscal layer 5a is involved in the processing of whisker motion, whereas the lemniscal barrels in layer 4 are involved in the processing of object identity.
Details
- Title
- Layer-specific touch-dependent facilitation and depression in the somatosensory cortex during active whisking
- Creators
- Dori Derdikman (null) - 972WIS_INST___123Chunxiu Yu (null)Sebastian Haidarliu (null) - 972WIS_INST___123Knarik Bagdasarian (null) - 972WIS_INST___123Amos Arieli (null) - 972WIS_INST___123Ehud Ahissar (Corresponding Author) - 972WIS_INST___123
- Resource Type
- Journal article
- Publication Details
- Journal of Neuroscience, Vol.26(37), pp.9538-9547; Sep/2006
- Number of pages
- 10
- Language
- English
- DOI
- https://doi.org/10.1523/JNEUROSCI.0918-06.2006
- Grant note
- This work was supported by the Israel Science Foundation, the Minerva Foundation with funding from the Federal German Ministry for Education and Research, the German Federal Ministry of Education and Research–Israeli Ministry of Science and Technology Foundation, and the Human Frontier Science Program. D.D. was supported by a fellowship from the Center for Complexity Science (Jerusalem, Israel). K.B. was supported by the Giladi program, Ministry of Absorption(Israel). E.A. holds the Helen Diller Family Professorial Chair of Neurobiology. We thank Jaime Heiss, Per Magne Knutsen, Ilan Lampl, Marcin Szwed, Barbara Schick, and the two anonymous reviewers for useful comments on this manuscript and Daniel Goldian and Naama Rubin for technical assistance
- Record Identifier
- 993264738803596
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