Journal article
Direct Synthesis of Pyrroles by Dehydrogenative Coupling of β‐Aminoalcohols with Secondary Alcohols Catalyzed by Ruthenium Pincer Complexes
Angewandte Chemie - International Edition, Vol.52(14), pp.4012-4015
2013
Abstract
Pyrroles were synthesized in one step by using the acceptorless dehydrogenative coupling of amino alcohols with secondary alcohols (equivalent amounts), catalyzed by ruthenium pincer complexes (0.5 mol %) and a base (less than stoichiometric amounts) through selective C-N and C-C bond formation. This atom‐economical, environmentally friendly methodology offers easy access to a range of substituted pyrroles in moderate to good yields.
Details
- Title
- Direct Synthesis of Pyrroles by Dehydrogenative Coupling of β‐Aminoalcohols with Secondary Alcohols Catalyzed by Ruthenium Pincer Complexes
- Creators
- Dipankar Srimani (null) - The Weizmann Institute of ScienceYehoshoa Ben-David (null) - The Weizmann Institute of ScienceDavid Milstein (null) - The Weizmann Institute of Science
- Resource Type
- Journal article
- Publication Details
- Angewandte Chemie - International Edition, Vol.52(14), pp.4012-4015; 2013
- Number of pages
- 4
- Language
- English
- DOI
- https://doi.org/10.1002/anie.201300574
- Grant note
- This research was supported by the European Research Council under the FP7 framework (ERC No 246837) and by the MINERVA Foundation. D. M. holds the Israel Matz Professorial Chair of Organic Chemistry._ALMAME_DELIMITER_
- Record Identifier
- 993264401603596
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