Diet-microbiota interactions and personalized nutrition

Aleksandra A Kolodziejczyk; Danping Zheng; Eran Elinav

doi:10.1038/s41579-019-0256-8

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Diet-microbiota interactions and personalized nutrition

Journal article

an open version is available

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Diet-microbiota interactions and personalized nutrition

Aleksandra A Kolodziejczyk, Danping Zheng and Eran Elinav

Nature Reviews. Microbiology, Vol.17(12), pp.742-753

20/Sep/2019

DOI: https://doi.org/10.1038/s41579-019-0256-8

PMID: 31541197

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Abstract

Conceptual scientific and medical advances have led to a recent realization that there may be no single, one-size-fits-all diet and that differential human responses to dietary inputs may rather be driven by unique and quantifiable host and microbiome features. Integration of these person-specific host and microbiome readouts into actionable modules may complement traditional food measurement approaches in devising diets that are of benefit to the individual. Although many host-derived factors are hardwired and difficult to modulate, the microbiome may be more readily reshaped by environmental factors such as dietary exposures and is increasingly recognized to potentially impact human physiology by participating in digestion, the absorption of nutrients, shaping of the mucosal immune response and the synthesis or modulation of a plethora of potentially bioactive compounds. Thus, diet-induced microbiota alterations may be harnessed in order to induce changes in host physiology, including disease development and progression. However, major limitations in ‘big-data’ processing and analysis still limit our interpretive and translational capabilities concerning these person-specific host, microbiome and diet interactions. In this Review, we describe the latest advances in understanding diet–microbiota interactions, the individuality of gut microbiota composition and how this knowledge could be harnessed for personalized nutrition strategies to improve human health.

Immune response

Mucosal immunity

Nutrition

Immunomodulation

Microbiomes

Environmental factors

Microbiota

Diet

Data management

Bioactive compounds

Nutrients

Human behavior

Disease Control

Physiology

Details

Title: Diet-microbiota interactions and personalized nutrition
Creators: Aleksandra A Kolodziejczyk - 972WIS_INST___121
Danping Zheng - 972WIS_INST___121
Eran Elinav - 972WIS_INST___121
Resource Type: Journal article
Publication Details: Nature Reviews. Microbiology, Vol.17(12), pp.742-753; 20/Sep/2019
Publisher: Nature Publishing Group; London
Language: English
DOI: https://doi.org/10.1038/s41579-019-0256-8
PMID: 31541197
Record Identifier: 992976920303596

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