Journal article
Determinants of nucleosome positioning
Nature Structural & Molecular Biology, Vol.20(3), pp.267-273
Mar/2013
Abstract
Nucleosome positioning is critical for gene expression and most DNA-related processes. Here we review the dominant patterns of nucleosome positioning that have been observed and summarize the current understanding of their underlying determinants. The genome-wide pattern of nucleosome positioning is determined by the combination of DNA sequence, ATP-dependent nucleosome remodeling enzymes and transcription factors that include activators, components of the preinitiation complex and elongating RNA polymerase II. These determinants influence each other such that the resulting nucleosome positioning patterns are likely to differ among genes and among cells in a population, with consequent effects on gene expression.
Details
- Title
- Determinants of nucleosome positioning
- Creators
- Kevin Struhl (null)Eran Segal (null) - 972WIS_INST___83
- Resource Type
- Journal article; Review
- Publication Details
- Nature Structural & Molecular Biology, Vol.20(3), pp.267-273; Mar/2013
- Number of pages
- 7
- Language
- English
- DOI
- https://doi.org/10.1038/nsmb.2506
- Grant note
- US National Institutes of Health [GM 30186]; European Research Council; US National Institutes of HealthThis Review is dedicated to the memory of Jon Widom, our dear friend and colleague, who is sorely missed by the authors and the scientific community We thank D. Schneider for encouraging us to write this Review, and Z. Moqtaderi, T. Raveh-Sadka, M. Levo, N. Kaplan and Y. Field for comments on the manuscript. This work was supported by grant GM 30186 from the US National Institutes of Health to K.S. and grants from the European Research Council and the US National Institutes of Health to E.S._ALMAME_DELIMITER_
- Record Identifier
- 993266847703596
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