Journal article
Curcumin inhibits hepatitis B virus via down-regulation of the metabolic coactivator PGC-1 alpha
FEBS Letters, Vol.584(11), pp.2485-2490
Jun/2010
Abstract
Hepatitis B virus (HBV) infects the liver and uses its cell host for gene expression and propagation. Therefore, targeting host factors essential for HBV gene expression is a potential anti-viral strategy. Here we show that treating HBV expressing cells with the natural phenolic compound curcumin inhibits HBV gene expression and replication. This inhibition is mediated via down-regulation of PGC-1 alpha, a starvation-induced protein that initiates the gluconeogenesis cascade and that has been shown to robustly coactivate HBV transcription. We suggest curcumin as a host targeted therapy for HBV infection that may complement current virus-specific therapies.
Details
- Title
- Curcumin inhibits hepatitis B virus via down-regulation of the metabolic coactivator PGC-1 alpha
- Creators
- Maya Mouler Rechtman (null)Iddo Bar-Yishay (null)Sigal Fishman (null)Yaarit Adamovich (null) - 972WIS_INST___112Yosef Shaul (null) - 972WIS_INST___111Zamir Halpern (null)Amir Shlomai (null)
- Resource Type
- Journal article
- Publication Details
- FEBS Letters, Vol.584(11), pp.2485-2490; Jun/2010
- Number of pages
- 6
- Language
- English
- DOI
- https://doi.org/10.1016/j.febslet.2010.04.067
- Grant note
- Sackler faculty of Medicine, Tel-Aviv University; United States-Israel Binational Science Foundation (BSF) [2007285]This work was supported by the following Grants: Schraiber Grant from the Sackler faculty of Medicine, Tel-Aviv University, The Weizmann-Ichilov Joint Grant and Grant No. 2007285 from the United States-Israel Binational Science Foundation (BSF)._ALMAME_DELIMITER_
- Record Identifier
- 993267346503596
Metrics
6 Record Views