The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release.
Journal article
Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety
Nature Neuroscience, Vol.21(6)
Jun/2018
Abstract
Details
- Title
- Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety
- Creators
- Nina Dedic (null) - Max Planck Institute of PsychiatryClaudia Kuehne (null) - Max Planck Institute of PsychiatryMira Jakovcevski (null) - Max Planck Institute of PsychiatryJakob Hartmann (null) - McLean HospitalAndreas J. Genewsky (null) - Max Planck Institute of PsychiatryKarina S. Gomes (null) - Universidade Estadual PaulistaElmira Anderzhanova (null) - Max Planck Institute of PsychiatryMax L. Poehlmann (null) - Max Planck Institute of PsychiatrySimon Chang (null) - Max Planck Institute of PsychiatryAdam Kolarz (null) - Max Planck Institute of PsychiatryAnnette M. Vogl (null) - Max Planck Institute of PsychiatryJulien Dine (null) - Max Planck Institute of PsychiatryMichael W. Metzger (null) - Max Planck Institute of PsychiatryBianca Schmid (null) - Max Planck Institute of PsychiatryRafael C. Almada (null) - Max Planck Institute of PsychiatryKerry J. Ressler (null) - McLean HospitalCarsten T. Wotjak (null) - Max Planck Institute of PsychiatryValery Grinevich (null) - German Cancer Research CenterAlon Chen (null) - 972WIS_INST___123Mathias V. Schmidt (null) - Max Planck Institute of PsychiatryWolfgang Wurst (null) - German Center for Neurodegenerative DiseasesDamian Refojo (null) - Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck SocietyJan M. Deussing (Corresponding Author) - Max Planck Institute of Psychiatry
- Resource Type
- Journal article
- Publication Details
- Nature Neuroscience, Vol.21(6); Jun/2018
- Number of pages
- 8
- Language
- English
- DOI
- https://doi.org/10.1038/s41593-018-0151-z
- Grant note
- We thank S. Bauer, C. Eggert, D. Harbich, M. Holzapfel, R. Hüttl, A. Mederer, A. Parl,
A. Ressle, R. Stoffel, L. Tietze and S. Unkmeir for excellent technical support, M. Eder
for Core Unit infrastructure and J. Keverne for manuscript proofreading. This work was
partially supported by the Max Planck Society, Volkswagen Foundation, German Federal
Ministry of Education and Research (FKZ:01ZX1314H to J.M.D., W.W.), Helmholtz
Alliance ICEMED (to W.W.), Chica and Heinz Schaller Foundation (to V.G.), DFG
(SFB 1134 to V.G.) and FAPESP (2013/03445-3 to K.S.G.). - Record Identifier
- 993263843103596
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