Journal article
Cell-Cell Communication between Malaria-Infected Red Blood Cells via Exosome-like Vesicles
Cell, Vol.153(5), pp.1120-1133
May/2013
Abstract
Cell-cell communication is an important mechanism for information exchange promoting cell survival for the control of features such as population density and differentiation. We determined that Plasmodium falciparum-infected red blood cells directly communicate between parasites within a population using exosome-like vesicles that are capable of delivering genes. Importantly, communication via exosome-like vesicles promotes differentiation to sexual forms at a rate that suggests that signaling is involved. Furthermore, we have identified a P. falciparum protein, PfPTP2, that plays a key role in efficient communication. This study reveals a previously unidentified pathway of P. falciparum biology critical for survival in the host and transmission to mosquitoes. This identifies a pathway for the development of agents to block parasite transmission from the human host to the mosquito.
Details
- Title
- Cell-Cell Communication between Malaria-Infected Red Blood Cells via Exosome-like Vesicles
- Creators
- Neta Regev-Rudzki (null) - 972WIS_INST___112Danny W. Wilson (null)Teresa G. Carvalho (null)Xavier Sisquella (null)Bradley M. Coleman (null)Melanie Rug (null)Dejan Bursac (null)Fiona Angrisano (null)Michelle Gee (null)Andrew F. Hill (null)Jake Baum (null)Alan F. Cowman (null)
- Resource Type
- Journal article
- Publication Details
- Cell, Vol.153(5), pp.1120-1133; May/2013
- Number of pages
- 14
- Language
- English
- DOI
- https://doi.org/10.1016/j.cell.2013.04.029
- Grant note
- National Health and Medical Research Council (NHMRC) of Australia We thank the Red Cross Blood Service for erythrocytes and M. O'Neill, A. Maier, D. Dorin-Semblat, and C. Doerig for transgenic lines. We thank F. Fowkes for statistical advice and N. Dahan, M. Duffy, and J. Thompson for their advice in carrying out various assays. We thank the Advanced Microscopy Facility, Bio21 Molecular Science and Biotechnology Institute, and the Melbourne Materials Institute (MMI) for microscopy equipment. 3D-SIM was performed at the Biological Optical Microscopy Platform, University of Melbourne (http://www.microscopy.unimelb.edu.au/bomp.html). This work was supported by National Health and Medical Research Council (NHMRC) of Australia and Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS. N.R.-R. is supported by a Rothschild Fellowship and the Hebrew University of Jerusalem. D.W. and N.R.-R. are supported by Early Career Fellowships from NHMRC. A.F.H. is an ARC Future Fellow and honorary NHMRC Senior Research Fellow. A.F.C. is a Howard Hughes International Scholar._ALMAME_DELIMITER_
- Record Identifier
- 993268098603596
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