Journal article
CYTOTOXICITY EFFECTS OF TRANSITION-METAL CHELATORS OF THE 5-SUBSTITUTED 2-HYDROXYACETOPHENONES AND THEIR OXIMES
European Journal of Medicinal Chemistry, Vol.30(8-Jul), pp.553-560
1995
Abstract
A series of 5-substituted 2-hydroxyacetophenones (A) and their oxime derivatives (B) were synthesized, and their cytotoxic activities towards MCF-7 breast cancer cells and B-16 melanoma cells were compared. The substitution on the benzylic position enabled variation of the lipophilic nature of the compound, while the chelating site remained free for metal binding. The results obtained indicate that the lipophilic properties of the compounds are favorable for cytotoxicity activity and that the oximes which are lipophilic enough (eg, B-4, B-5, B-9) are more potent than the corresponding ketones (A-4, A-5, A-9). All the potent oximes examined in this work showed strong cardiotoxicity.
Details
- Title
- CYTOTOXICITY EFFECTS OF TRANSITION-METAL CHELATORS OF THE 5-SUBSTITUTED 2-HYDROXYACETOPHENONES AND THEIR OXIMES
- Creators
- A WARSHAWSKY (null)Nava Kahana (null) - The Weizmann Institute of ScienceE BEERY (null)G KESSLERICEKSON (null)A NOVOGRODSKY (null)J NORDENBERG (null)
- Resource Type
- Journal article
- Publication Details
- European Journal of Medicinal Chemistry, Vol.30(8-Jul), pp.553-560; 1995
- Number of pages
- 8
- Language
- English
- DOI
- https://doi.org/10.1016/0223-5234(96)88269-9
- Scientific Unit
- The Weizmann Institute of Science
- Record Identifier
- 993263376403596
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