Journal article
Artificial sweeteners induce glucose intolerance by altering the gut microbiota
Nature, Vol.514(7521), pp.181-186
17/Oct/2014
Abstract
Non-caloric artificial sweeteners (NAS) are among the most widely used food additives worldwide, regularly consumed by lean and obese individuals alike. NAS consumption is considered safe and beneficial owing to their low caloric content, yet supporting scientific data remain sparse and controversial. Here we demonstrate that consumption of commonly used NAS formulations drives the development of glucose intolerance through induction of compositional and functional alterations to the intestinal microbiota. These NAS-mediated deleterious metabolic effects are abrogated by antibiotic treatment, and are fully transferrable to germ-free mice upon faecal transplantation of microbiota configurations from NAS-consuming mice, or of microbiota anaerobically incubated in the presence of NAS. We identify NAS-altered microbial metabolic pathways that are linked to host susceptibility to metabolic disease, and demonstrate similar NAS-induced dysbiosis and glucose intolerance in healthy human subjects. Collectively, our results link NAS consumption, dysbiosis and metabolic abnormalities, thereby calling for a reassessment of massive NAS usage.
Details
- Title
- Artificial sweeteners induce glucose intolerance by altering the gut microbiota
- Creators
- Jotham Suez (null) - 972WIS_INST___120Tal Korem (null) - 972WIS_INST___83David Zeevi (null) - 972WIS_INST___83Gili Zilberman-Schapira (null) - 972WIS_INST___120Christoph Alexander Thaiss (null) - 972WIS_INST___120Ori Maza (null) - The Weizmann Institute of ScienceDavid Israeli (null) - Hadassah Medical CenterNiv Zmora (null) - 972WIS_INST___120Shlomit Gilad (null) - 972WIS_INST___971Adina Weinberger (null) - 972WIS_INST___83Yael Kuperman (null) - 972WIS_INST___130Alon Harmelin (null) - 972WIS_INST___130Ilana Kolodkin-Gal (null) - 972WIS_INST___111Hagit Shapiro (null) - 972WIS_INST___120Zamir Halpern (null) - Tel Aviv Sourasky Medical CenterEran Segal (null) - 972WIS_INST___83Eran Elinav (null) - 972WIS_INST___120
- Resource Type
- Journal article
- Publication Details
- Nature, Vol.514(7521), pp.181-186; 17/Oct/2014
- Number of pages
- 17
- Language
- English
- DOI
- https://doi.org/10.1038/nature13793
- Grant note
- Weizmann Institute management; Nancy and Stephen Grand Israel National Center for Personalized Medicine (INCPM); Boehringer Ingelheim Fonds PhD Fellowship; Morris Kahn Fellowships for Systems Biology; National Institute of Health (NIH); European Research Council (ERC); Abisch Frenkel Foundation for the Promotion of Life Sciences; Gurwin Family Fund for Scientific Research; Leona M. and Harry B. Helmsley Charitable Trust; Crown Endowment Fund for Immunological Research; estate of J. Gitlitz; estate of L. Hershkovich; Rising Tide foundation; Minerva Stiftung foundation; European Research Council. We thank the members of the Elinav and Segal laboratories for discussions. We acknowledge C. Bar-Nathan for germ-free mouse caretaking. We thank the Weizmann Institute management and the Nancy and Stephen Grand Israel National Center for Personalized Medicine (INCPM) for providing financial and infrastructure support. We thank G. Malka, N. Kosower and R. Bikovsky for coordinating the human clinical trials, and M. Pevsner-Fischer, T. Avnit-Sagi and M. Lotan-Pompan for assistance with microbiome sample processing. C.A.T. is the recipient of a Boehringer Ingelheim Fonds PhD Fellowship. G.Z.-S. is supported by the Morris Kahn Fellowships for Systems Biology. This work was supported by grants from the National Institute of Health (NIH) and the European Research Council (ERC) to E. S., and support and grants to E. E. provided by Y. and R. Ungar, the Abisch Frenkel Foundation for the Promotion of Life Sciences, the Gurwin Family Fund for Scientific Research, Leona M. and Harry B. Helmsley Charitable Trust, Crown Endowment Fund for Immunological Research, estate of J. Gitlitz, estate of L. Hershkovich, Rising Tide foundation, Minerva Stiftung foundation, and the European Research Council. E.E. is the incumbent of the Rina Gudinski Career Development Chair._ALMAME_DELIMITER_
- Record Identifier
- 993267111703596
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