Journal article
A VIP ANTAGONIST DISTINGUISHES VIP RECEPTORS ON SPINAL-CORD CELLS AND LYMPHOCYTES
Brain Research, Vol.540(2-Jan), pp.319-321
Feb/1991
Abstract
Vasoactive intestinal peptide (VIP) is a neuropeptide which also interacts with cells of the immune system. The paucity of specific VIP receptor antagonists has hampered studies of possible receptor heterogeneity and of VIP function. To aid in achieving these goals, a new VIP antagonist, a hybrid between neurotensin and VIP, has been synthesized. This peptide interacted with VIP receptors on spinal cord cells with an affinity 10-fold greater than VIP itself. In contrast, 1000-fold higher concentrations of the antagonist were required to displace labeled VIP from its receptor on lymphoid cells as compared to VIP itself, suggesting VIP receptor heterogeneity between immune and spinal cord cells.
Details
- Title
- A VIP ANTAGONIST DISTINGUISHES VIP RECEPTORS ON SPINAL-CORD CELLS AND LYMPHOCYTES
- Creators
- Y GOZES (null)DE BRENNEMAN (null)Matityahu Fridkin (null) - The Weizmann Institute of ScienceR ASOFSKY (null)I GOZES (null)
- Resource Type
- Journal article
- Publication Details
- Brain Research, Vol.540(2-Jan), pp.319-321; Feb/1991
- Number of pages
- 3
- Language
- English
- DOI
- https://doi.org/10.1016/0006-8993(91)90528-4
- Scientific Unit
- The Weizmann Institute of Science
- Record Identifier
- 993266863703596
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