Journal article
A Dual Program for Translation Regulation in Cellular Proliferation and Differentiation
Cell, Vol.158(6), pp.1281-1292
Sep/2014
Abstract
A dichotomous choice for metazoan cells is between proliferation and differentiation. Measuring tRNA pools in various cell types, we found two distinct subsets, one that is induced in proliferating cells, and repressed otherwise, and another with the opposite signature. Correspondingly, we found that genes serving cell-autonomous functions and genes involved in multicellularity obey distinct codon usage. Proliferation-induced and differentiation-induced tRNAs often carry anticodons that correspond to the codons enriched among the cell-autonomous and the multicellularity genes, respectively. Because mRNAs of cell-autonomous genes are induced in proliferation and cancer in particular, the concomitant induction of their codon-enriched tRNAs suggests coordination between transcription and translation. Histone modifications indeed change similarly in the vicinity of cell-autonomous genes and their corresponding tRNAs, and in multicellularity genes and their tRNAs, suggesting the existence of transcriptional programs coordinating tRNA supply and demand. Hence, we describe the existence of two distinct translation programs that operate during proliferation and differentiation.
Details
- Title
- A Dual Program for Translation Regulation in Cellular Proliferation and Differentiation
- Creators
- Hila Gingold (null) - 972WIS_INST___111D Tehler (null)NR Christoffersen (null)MM Nielsen (null)F Asmar (null)SM Kooistra (null)NS Christophersen (null)LL Christensen (null)M Borre (null)KD Sorensen (null)LD Andersen (null)CL Andersen (null)E Hulleman (null)T Wurdinger (null)E Ralfkiaer (null)K Helin (null)K Gronbaek (null)T Omtoft (null)SM Waszak (null)Orna Dahan (null) - 972WIS_INST___111JS Pedersen (null)AH Lund (null)Yitzhak Pilpel (null) - 972WIS_INST___111
- Resource Type
- Journal article
- Publication Details
- Cell, Vol.158(6), pp.1281-1292; Sep/2014
- Number of pages
- 12
- Language
- English
- DOI
- https://doi.org/10.1016/j.cell.2014.08.011
- Grant note
- European Research Council (ERC) grant; Danish National Advanced Technology Foundation; Danish Council for Strategic Research; Danish Council for Independent Research; Novo Nordisk Foundation; Lundbeck Foundation; Danish Cancer Society; Netherlands Organisation for scientific research (NWO); Danish National Research Foundation [DNRF82] Work in the authors' laboratory is supported by a European Research Council (ERC) grant (Y.P.) and by the Danish National Advanced Technology Foundation, the Danish Council for Strategic Research, the Danish Council for Independent Research, the Novo Nordisk Foundation, the Lundbeck Foundation, and the Danish Cancer Society (A.H.L.). Y.P. is an incumbent of the Ben-May Professorial Chair. S.M.K. was supported by a postdoctoral fellowship from the Netherlands Organisation for scientific research (NWO). The Centre for Epigenetics is supported by the Danish National Research Foundation (DNRF82). We thank Simon Kasif and Erez Dekel for stimulating discussions._ALMAME_DELIMITER_
- Record Identifier
- 993262719703596
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