Abstract
Prostate cancer: Accurate determination of extracapsular extension with high-spatial-resolution dynamic contrast-enhanced and T2-weighted MR imaging - Initial results
Radiology, Vol.245(1), pp.176-185
88th Scientific Assembly and Annual Meeting of the Radiological-Society-of-North-America (CHICAGO, IL, 01/Dec/2002 - 06/Dec/2002)
Oct/2007
Abstract
Purpose: To prospectively compare the sensitivity and specificity of high-spatial-resolution dynamic contract material-enhanced magnetic resonance (MR) imaging with those of high-spatial-resolution T2-weighted MR imaging, performed with an endorectal coil (ERC), for assessment of extracapsular extension (ECE) and staging in patients with prostate cancer, with histopathologic findings as reference. Materials and Methods: The study was approved by the institutional internal review board; a signed informed consent was obtained. MR imaging of the prostate at 1.5 T was performed with combined surface coils and ERCs in 32 patients (mean age, 65 years; range, 42-78 years) before radical prostatectomy. High-spatial-resolution T2-weighted fast spin-echo and high-spatial-resolution dynamic contrast-enhanced three-dimensional gradient-echo images were acquired with gadopentetate dimeglumine. Dynamic contrast-enhanced MR images were analysed with a computer-generated color-coded scheme. Two experienced readers independently assessed ECE and tumor stage. MR imaging-based staging results were compared with histopathologic results. For the prediction of ECE, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated. Staging accuracy was determined with the area under the receiver operating characteristic curve (AUC) by using the Wilcoxon-Mann-Whitney index of diagnostic accuracy. Results: The mean sensitivity, specificity, PPV, and NPV for assessment of ECE with the combined data sets for both readers were 86%, 95%, 90%, and 93%, respectively. The sensitivity of MR images for determination of ECE was significantly improved for both readers (>25%) with combined data sets compared with T2-weighted MR images alone. The combined data sets had a mean overall staging accuracy for both readers of 95%, as determined with AUC. Staging results for both readers were significantly improved (P
Details
- Title
- Prostate cancer; Accurate determination of extracapsular extension with high-spatial-resolution dynamic contrast-enhanced and T2-weighted MR imaging - Initial results
- Creators
- B. Nicolas Bloch (null)Edna Furman-Haran (null) - 972WIS_INST___113Thomas H. Helbich (null)Robert E. Lenkinski (null)Hadassa Degani (null) - The Weizmann Institute of ScienceChristian Kratzik (null)Martin Susani (null)Andrea Haitel (null)Silvia Jaromi (null)Long Ngo (null)Neil M. Rofsky (null)
- Resource Type
- Abstract
- Publication Details
- Radiology, Vol.245(1), pp.176-185; Oct/2007
- Number of pages
- 10
- Language
- English
- DOI
- https://doi.org/10.1148/radiol.2451061502
- Conference
- 88th Scientific Assembly and Annual Meeting of the Radiological-Society-of-North-America (CHICAGO, IL, 01/Dec/2002 - 06/Dec/2002)
- Record Identifier
- 993267441603596
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